Professor Holder jointly qualified in Clinical Medicine and Biophysics from Cambridge University and University College Hospital. He then undertook a Master’s degree in Biophysics at the University of California, Berkeley and a PhD in Physiology at UCL. He held an MRC training fellowship and then Royal Society University Research Fellowship at University College London before taking a position as Consultant in Clinical Neurophysiology at the Middlesex Hospital and UCH.
He has lead the Neurophysiology department at UCH which undertakes EMG, EEG and nerve conduction studies since 1997. He also leads a multidisciplinary neurophysiology/bioengineering research group in Medical Physics at UCL. This is developing new methods to image function in the brain and peripheral nervous system and is currently funded by the Medical Research Council, National Institutes of Health USA, Glaxo Smith Kline and Google Health. It has pioneered the new method of Electrical Impedance Tomography for this purpose. This provides a new tool in clinical neuroscience as it can provide 3D images of fast neural activity over milliseconds in the brain and peripheral nerves.
In November 2018 Professor Holder was granted Practising Privileges at King Edward VII’s Hospital, Marylebone, where he practises as part of The London Orthopaedic Clinic.